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| Santos,Edson N.; Lima,Joaquim C.S.; Noldin,Vânia F.; Cechinel-Filho,Valdir; Rao,Vietla S. N.; Lima,Evangelista F.; Schmeda-Hirschmann,Guillermo; Sousa Jr.,Paulo T.; Martins,Domingos T.O.. |
| Cariniana rubra Miers (Lecythidaceae), popularly known as "jequitibá-vermelho'', is a large Brazilian tree whose bark is used in infusion and decoction for the treatment of inflammatory conditions. This study aims to assess the anti-inflammatory, antinociceptive, and antipyretic effects of Cariniana rubra methanolic stem bark extract (EM Cr) using experimental animals. Anti-inflammatory activity of EM Cr was tested on carrageenan and dextran-induced rat paw edema, carrageenan-induced pleurisy in rats and acetic acid-increase vascular permeability in mice. Antinociceptive and antipyretic activities were evaluated using acetic acid-induced writhing, formalin and hot-plate tests in mice, as well as brewer's yeast-induced pyrexia in rats. The extract... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Anti-inflammatory; Antinociceptive; Antipyretic; Cariniana rubra; Lecythidaceae; Triterpenoidal saponins. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652011000200015 |
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| Barros,Wander M.; Rao,Vietla S.N.; Silva,Regilane M.; Lima,Joaquim C.S.; Martins,Domingos T.O.. |
| Bowdichia virgilioides H.B.K stem bark (Fabaceae), locally known as "sucupira-preta", is a reputed folk-remedy to treat some inflammatory disorders. To validate its traditional claim, the ethanolic extract from B. virgilioides was evaluated in several animal models of inflammation and nociception. The extract at oral doses of 100 to 1000 mg/kg body weight caused a significant inhibition of carrageenan-induced hind paw oedema, suppression of exudate volume and leukocyte immigration in rat pleurisy induced by carrageenan, and reduction of granuloma weights in the model of subcutaneous granulomas promoted by cotton pellets. In addition, the plant extract significantly inhibited the vascular permeability increase induced by intraperitoneal acetic acid. It also... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bowdichia virgilioides; Fabaceae; Stem bark extract; Anti-inflammatory activity. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652010000300008 |
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